Open Access
Research
(Published
online: 28-05-2016)
16.
Comparative efficacy of anthelmintics and
their effects on hematobiochemical changes in fasciolosis of
goats of South Gujarat -
R. G. Shrimali, M. D. Patel and R. M. Patel
Veterinary World, 9(5): 524-529
doi:
10.14202/vetworld.2016.524-529
R. G. Shrimali:
Department of Veterinary Medicine, College of Veterinary Science
& Animal Husbandry, Navsari Agricultural University, Navsari -
396 450, Gujarat, India; trivedironak89@yahoo.in
M. D. Patel:
Department of Veterinary Medicine, College of Veterinary Science
& Animal Husbandry, Navsari Agricultural University, Navsari -
396 450, Gujarat, India; drmanish911@yahoo.com
R. M. Patel:
Department of Veterinary Medicine, College of Veterinary Science
& Animal Husbandry, Navsari Agricultural University, Navsari -
396 450, Gujarat, India; rmpatel05@gmail.com
Received: 14-12-2015, Accepted: 14-04-2016, Published online:
28-05-2016
Corresponding author:
M. D. Patel, e-mail: drmanish911@yahoo.com
Citation:
Shrimali RG, Patel MD, Patel RM (2016) Comparative efficacy of
anthelmintics and their effects on hemato-biochemical changes in
fasciolosis of goats of South Gujarat.
Veterinary World, 9(5):
524-529.
Abstract
Aim:
Fasciolosis is a parasitic disease caused by
Fasciola
spp. of the family
Fasciolidae (trematodes)
characterized by bottle jaw, anemia, progressive debility, and
potbelly condition. There are many aspects of fasciolosis
remaining unknown thus hemato-biochemical alterations in
closantel, triclabendazole + ivermectin, and oxyclozanide +
levamisole treated goats were studied.
Materials and Methods:
A total of 40 naturally fasciolosis infected goats having egg
per gram more than 100 were randomly divided into four groups.
Goats of Group I-III were treated with three different
anthelmintics, whereas, goats of Group-IV were kept as control
or untreated. Whole blood, serum, and fecal samples were
collected on 0, 7th, and 30th day of
treatment.
Results:
During the study, values of hemoglobin, total erythrocyte count,
pack cell volume, and total protein were significantly elevated
to their normal levels in anthelmintics treated groups. Whereas,
values of total leukocyte count, aspartate transaminase (AST),
lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT)
were significantly reduced to their normal level in
anthelmintics treated groups. The efficacy of closantel (T1),
triclabendazole + ivermectin (T2), and oxyclozanide + levamisole
(T3) was 99.63%, 100%, and 94.74% and 100%, 100%, and 97.38% on
7th and 30th day of treatment,
respectively.
Conclusions:
Fasciolosis in goats can be diagnosed on the basis of fecal
sample examination, but alterations in important biomarkers such
as AST, GGT, and LDH are also helpful for early diagnosis. The
use of newer anthelmintic either alone or in combination showed
a higher therapeutic response in fasciolosis of goats.
Keywords:
anthelmintics, efficacy, fasciolosis, goats, hemato-biochemical
changes.
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