Open Access
Research
(Published
online: 02-11-2016)
2.
Clinico-anesthetic changes following
administration of propofol alone and in combination of
meperidine and pentazocine lactate in dogs -
A. K. Anandmay, L. L. Dass, A. K. Sharma, M. K. Gupta, K. K.
Singh and B. K.Roy
Veterinary World, 9(11): 1178-1183
doi:
10.14202/vetworld.2016.1178-1183
A. K. Anandmay:
Touring Veterinary Officer, Department of Animal Husbandry,
Adardih Block, Saraikella - 832 401, Jharkhand, India;
anandanandmay@gmail.com
L. L. Dass:
Department of Veterinary Surgery and Radiology, Ranchi
Veterinary College, Birsa Agricultural University, Ranchi - 834
006, Jharkhand, India; lalit.das50@gmail.com
A. K. Sharma:
Department of Veterinary Surgery and Radiology, Ranchi
Veterinary College, Birsa Agricultural University, Ranchi - 834
006, Jharkhand, India; arsham10@ rediffmail.com
M. K. Gupta:
Department of Veterinary Pathology, Ranchi Veterinary College,
Birsa Agricultural University, Ranchi - 834 006, Jharkhand,
India; madhurendu.gupta@gmail.com
K. K. Singh:
Department of Veterinary Pathology, Ranchi Veterinary College,
Birsa Agricultural University, Ranchi - 834 006, Jharkhand,
India; singhkkpatho@gmail.com
B. K.Roy:
Department of Veterinary Pharmacology and Toxicology, Ranchi
Veterinary College, Birsa Agricultural University, Ranchi - 834
006, Jharkhand, India; bkroy2001@yahoo.co.in
Received: 29-01-2016, Accepted: 17-09-2016, Published online:
02-11-2016
Corresponding author:
A. K. Sharma, e-mail: arsham10@ rediffmail.com
Citation:
Anandmay AK, Dass LL, Sharma AK, Gupta MK, Singh KK, Roy BK
(2016) Clinico-anesthetic changes following administration of
propofol alone and in combination of meperidine and pentazocine
lactate in dogs,
Veterinary World, 9(11):
1178-1183.
Abstract
Aim:
The aim of this study is to find out the effect of propofol and
its combination with meperidine and pentazocine lactate on
certain clinico-anesthetic profiles in dogs.
Materials and Methods:
15 apparently healthy mongrel dogs of either sex of about 1 year
of age were randomly divided into three groups of five dogs
each. The animals of Group I were administered propofol
intravenously alone “to effect,” whereas meperidine at 2 mg/kgb.wt.
and pentazocine lactate at 2 mg/kg b.wt. were injected
intramuscularly 15 min before propofol “to effect” in Groups II
and III, respectively. Atropine sulfate at 0.04 mg/kgb.wt. was
injected intramuscularly 20 min before each treatment. Rectal
temperature, heart rate, respiration rate, and anesthetic
indices were recorded before and at 5, 10, 20, 30, and 60 min of
induction.
Results:
As compared to Group I, the animals of Groups II and III
exhibited a significant decrease (p<0.05) in the level of rectal
temperature, respiration rate, and heart rate. Duration of
recumbency, time of standing, time of recovery as well as the
duration of analgesia were longer in pentazocine lactate (Group
III) followed by meperidine (Group II) as compared to propofol
alone (Group I). Meperidine treated dogs showed defecation and
muscle twitching during anesthesia.
Conclusion:
Meperidine and pentazocine are suitable opioids used in
combination with propofol for achieving surgical anesthesia and
helpful in reduction of propofol dose.
Keywords:
clinico-anesthetic changes, dog, meperidine, pentazocine,
propofol.
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