Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Research (Published online: 19-02-2018)

20. Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs

Ahmed G. Hegazi, Kadria N. Abdel Megeed, Soad E. Hassan, M. M. Abdelaziz, Nagwa I. Toaleb, Eman E. El Shanawany and Dina Aboelsoued

Veterinary World, 11(2): 215-220

Ahmed G. Hegazi: Department of Zoonotic Diseases, National Research Centre, Dokki, Giza, Egypt.

Kadria N. Abdel Megeed: Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.

Soad E. Hassan: Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.

M. M. Abdelaziz: Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.

Nagwa I. Toaleb: Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.

Eman E. El Shanawany: Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.

Dina Aboelsoued: Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.

doi: 10.14202/vetworld.2018.215-220

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Article history: Received: 14-09-2017, Accepted: 10-01-2018, Published online: 19-02-2018

Corresponding author: Dina Aboelsoued

E-mail: Dr.Dina.Aboelsoued@gmail.com

Citation: Hegazi AG, Abdel Megeed KN, Hassan SE, Abdelaziz MM, Toaleb NI, El Shanawany EE, Aboelsoued D (2018) Comparative ovicidal activity of Moringa oleifera leaf extracts on Fasciola gigantica eggs, Veterinary World, 11(2): 215-220.

Abstract

Background: Fasciolosis is an important zoonotic disease affecting the productive performance of farm animals in Egypt.

Aim: The aim of the present study was comparing the ovicidal effect of different extracts as an alcoholic (Methanolic and Ethanolic) and aqueous Moringa oleifera leaf extracts on Fasciola gigantica non-embryonated and developed eggs.

Materials and Methods: Tested concentrations of extracts ranged from 12.5 to 800 mg/ml. Nitroxynil was used as reference drug with a dose of 100 mg/ml.

Results: M. oleifera alcoholic and aqueous extracts showed a concentration-dependent ovicidal effect on F. gigantica non-embryonated and developed eggs. Based on LC₅₀ values, water extract showed the highest ovicidal activity since it registered the lowest values of 2.6 mg/ml on non-embryonated eggs. Non-embryonated eggs were more susceptible to aqueous extract than developed eggs. On the other hand, the developed eggs were more susceptible to ethanolic extract than non-embryonated eggs even the lowest LC₅₀ (12.38 mg/ml).

Conclusion: M. oleifera leaf extracts especially aqueous extract could be a promising step in the field of controlling fascioliasis. Further, in vivo studies are needed to enlighten the therapeutic potential of M. oleifera extracts in treating F. gigantica infection.

Keywords: Fasciola gigantica, leaf extract, Moringa oleifera, nitroxynil, ovicidal activity.

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