Aim: This study aimed to provide a summary of all online available literature of published clinical and histopathological data regarding tumors affecting the reproductive tract of female sheep and goats. In addition, a detailed description of the clinical history, clinical findings, and gross and histopathological findings of one case of vaginal fibroma in an adult Awassi sheep is provided for the first time.

Materials and Methods: Internet search engines such as PubMed, ResearchGate, Scopus, ScienceDirect, and Google Scholar were used to collect all published articles in refereed journals from 2000 to 2018 regarding tumors and tumor-like lesions involving the reproductive tract of ewes and does.

Results: There are six published papers in sheep and nine in goats reporting various malignant and non-malignant tumors involving different parts of the reproductive tract. The most commonly diagnosed tumors of the reproductive tract were leiomyoma (six cases), adenocarcinoma (six cases), leiomyosarcoma (three cases), adenoma (one case), squamous cell carcinoma (one case), and metastatic signet ring cell carcinoma (one case). The most common sites of tumor formation were the uterus (10 cases), vulva/vagina (five cases), ovaries (four cases), cervix (four cases), and Bartholin's gland (one case). All affected animals were aged females (older than 3 years of age). In both ewes and does, the most frequently reported clinical symptoms were chronic weight loss, pyometra, hydrometra, vaginal bleeding, abnormal vaginal discharges, straining, pollakisurie, ascites, and abdominal distension.

Conclusion: Tumors of the reproductive organs in sheep and goats are not uncommon and should be considered in the differential diagnoses in cases with poor reproductive function.

Keywords: benign tumors, malignancy, reproductive tract, small ruminants.

1. Fubini, S. and Ducharme, N. (2016) Farm Animal Surgery. Elsevier, The Netherlands.

2. Agnew, D.W. and MacLachlan, N.J. (2017) Tumors of the genital system. In: Tumors in Domestic Animals. 5th ed. John Wiley and Sons, Inc., Hoboken. p689-722. [Crossref]

3. Whitney, K.M., Valentine, B.A. and Schlaffer, D.H. (2000) Caprine genital leiomyosarcoma. Vet. Pathol., 37(1): 89-94. [Crossref] [PubMed]

4. Uzal, F.A. and Puschner, B. (2008) Cervical leiomyoma in an aged goat leading to massive hemorrhage and death. Can. Vet. J., 49(2): 177-179.

5. Vemireddi, V., Langohr, L.M. and Thacker, H.L. (2007) Polypoid uterine leiomyosarcomas in a sheep. J. Vet. Diagn. Invest., 19(3): 309-312. [Crossref] [PubMed]

6. Abraham, S.C. (2007) Distinguishing gastrointestinal stromal tumors from their mimics: An update. Adv. Anat. Pathol., 14(3): 178-188. [Crossref] [PubMed]

7. Laurini, J.A. and Carter, J.E. (2010) Gastrointestinal stromal tumors: A review of the literature. Arch. Pathol. Lab. Med., 134(1): 134-141. [Crossref]

8. Ferrer, L.M., Lacasta, D., Ramos, J.J., Del Jalon, J.A.G., De Arcaute, M.R. and Conde, T. (2011) Squamous cell carcinoma of the vagina and cervix in sheep-case report. Acta Vet. Hung., 59(1): 125-129. [Crossref] [PubMed]

9. Kawashima, M., Segawa, R., Yoshida, T., Murayma, H., Nagahara, R., Kimura, M., Endo, M., Tanaka, T. and Shibutani, M. (2017) Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat. J. Vet. Med. Sci., 79(6): 1091-1095. [Crossref] [PubMed] [PMC]

10. Svara, T., Gombac, M., Juntes, P. and Pogacnik, M. (2009) Malignant ovarian granulosa cell tumor in a ewe. Acta Vet. Brno, 78(2): 281-285. [Crossref]

11. Lohr, C.V. (2012) One hundred two tumors in 100 goats (1987-2011). Vet. Pathol., 50(4): 668-675. [Crossref] [PubMed]

12. Moreira, J.R., de Oliveira, T.E.S., de Oliveira Tongu, E.A., Leite, R.O., Nogueira, G.M., Michelazzo, M.Z., Delfiol, D.J., Saut, J.E. and Headley, S.H. (2018) Bartholin's gland adenoma in a Saanen goat. Cienc. Rural, 48(1): e20170214. [Crossref]

13. Verberckmoes, S., de Bosschere, H., van Soom, A., Vervaet, P. and de Kruif, A. (2003) Intravaginal fibroma in a sheep. Vet. Rec., 152(18): 566-567. [Crossref]

14. Pfisterl, P., Geissbuehler, U., Wiener, D., Hirsbrunnerl, G. and Kaufmann, C. (2007) Pollakisuria in a dwarf goat due to pathologic enlargement of the uterus. Vet. Q., 29(3): 112-116. [Crossref] [PubMed]

15. Dockweiler, J.C., Cossic, B., McDonough, S.P., Fubini, S.L., Le, K.M., Donnelly, C.G., Gilbert, R.O. and Cheong, S.H. (2017) Tumor collision of uterine adenocarcinoma and leiomyosarcoma in a goat. J. Vet. Diagn. Invest., 29(5): 696-699. [Crossref] [PubMed]

16. Oultram, J.W. and Morgan, L. (2013) A case of pyometra and granulosa cell tumor in a sheep. Livestock, 18(4): 126-128. [Crossref]

17. Cooper, B.J. and Valentine, B.A. (2017) Tumors of muscle. In: Tumors in Domestic Animals. 5th ed. John Wiley and Sons, Inc., Iowa. p425-466. [Crossref]

18. Stern, A.W., Stewart, J.L., Chu, C. and Garrett, E. (2015) Signet-ring cell carcinoma in a goat. Vet. Q., 35(2): 111-115. [Crossref] [PubMed]

19. Corpa, J.M. and Martinez, C.M. (2010) Uterine leiomyoma in a sheep. Reprod. Domest. Anim., 45(4): 746-748.

20. Beena, V., Pawaiya, R.V.S., Singh, D.D., Gangwar, N.K., Shivasharanappa, N. and Gururaj, K. (2016) A case of composite neoplasm of ovary in a goat having histological features of thecoma and metastatic adenocarcinoma. Indian J. Vet. Pathol., 40(2): 177-180. [Crossref]