doi: 10.14202/vetworld.2019.1650-1656
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Article history: Received: 30-04-2019, Accepted: 06-09-2019, Published online: 28-10-2019
Corresponding author: Abeer Ahmed Majeed
E-mail: sabahali503@yahoo.com
Citation: Majeed AA, Abood DA (2019) Histological assessment of the efficiency of rabbit serum in healing skin wounds, Veterinary World, 12(10): 1650-1656.Aim: This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination.
Materials and Methods: A total of ten indigenous rabbits were used in this study. The animals were divided into two groups: control and serum- treated. The histological assessment was done with a paraffin embedding technique and the histological sections were stained with H&E stain.
Results: Severe infiltration of polymorphonuclear leukocytes with severe fibrin deposits were seen in serum treated group at 2 days post-injury; at 7 days post-injury the changes revealed moderate fibroplasia, fibrin deposit and severe infiltration of both mononuclear and polymorphonuclear leukocytes; at 14 days post-injury, there were marked epithelization and dermal deposition of collagen fibers; and at 21 days post-injury, the epidermis completed epithelization and the dermis showed neither fibroplasia nor infiltration of mononuclear and polymorphonuclear leukocytes.
Conclusion: The results indicated that rabbit's serum can prevent wound infection, accelerate epithelialization and cutaneous regeneration with less granulation.
Keywords: healing, rabbits, serum, skin, wounds.