Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease

Research (Published online: 14-05-2020)

9. Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease

Mahmoud Aly, Mohamed Nayel, Akram Salama, Emad Ghazy and Ibrahim Elshahawy

Veterinary World, 13(5): 890-895

Mahmoud Aly: Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt (Animal Medicine).

Mohamed Nayel: Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt (Infectious Diseases).

Akram Salama: Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt (Infectious Diseases).

Emad Ghazy: Department of Clinical Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.

Ibrahim Elshahawy: Department of Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Egypt.

doi: www.doi.org/10.14202/vetworld.2020.890-895

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Article history: Received: 23-12-2019, Accepted: 03-04-2020, Published online: 14-05-2020

Corresponding author: Mahmoud Aly

E-mail: allaamvet82@yahoo.com

Citation: Aly M, Nayel M, Salama A, Ghazy E, Elshahawy I (2020) Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease, Veterinary World, 13(5): 890-895.

Abstract

Background and Aim: Foot-and-mouth disease (FMD) causes huge economic losses in Egypt due to reductions in the production of red meat, milk, and milk by-products and can also lead to myocarditis in young animals. The aim of our study was to evaluate cardiac biomarkers, in particular cardiac troponin I (cTnI), and to reveal the relations of cardiac biomarkers with poor survival in FMD-infected Egyptian buffalo calves.

Materials and Methods: Forty-two Egyptian buffalo calves were included in this study. The calves were divided into 12 apparently healthy control calves and 30 calves clinically diagnosed with FMD during a disease outbreak in Menofia and Behera Governorates, Egypt. The diseased calves were divided, according to age, into 13 calves <3 months old and 17 calves between 3 and 6 months old. The animals were examined clinically and subjected to analysis of cardiac biomarkers.

Results: Biochemical analysis revealed significant elevations of cardiac biomarkers, especially creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in FMD-infected calves in comparison with control calves. There was a significant association between cTnI and poor survival in infected calves.

Conclusion: Cardiac biomarkers could be used as a rapid method for diagnosis of myocarditis induced by FMD in Egyptian buffalo calves. In addition, cTnI is a very sensitive and accurate tool for determining myocardial cell damage in the earlier stages of the disease and a good predictor of poor survival in calves.

Keywords: cardiac troponin I, Egyptian buffalo calves, foot-and-mouth disease, myocarditis.