Prevalence of cardiac myosin-binding protein C3 mutations in Maine Coon cats with hypertrophic cardiomyopathy

Research (Published online: 27-02-2022)

34. Prevalence of cardiac myosin-binding protein C3 mutations in Maine Coon cats with hypertrophic cardiomyopathy

Pratch Sukumolanan and Soontaree Petchdee

Veterinary World, 15(2): 502-508

Pratch Sukumolanan: Veterinary Clinical Studies Program, Graduate School, Kasetsart University, Kamphaeng Saen Campus, Nakorn Pathom, 73140, Thailand.

Soontaree Petchdee: Department of Large Animal and Wildlife Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakorn Pathom, 73140, Thailand.

doi: www.doi.org/10.14202/vetworld.2022.502-508

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Article history: Received: 07-10-2021, Accepted: 24-01-2022, Published online: 27-02-2022

Corresponding author: Soontaree Petchdee

E-mail: fvetstr@ku.ac.th

Citation: Sukumolanan P, Petchdee S (2022) Prevalence of cardiac myosin-binding protein C3 mutations in Maine Coon cats with hypertrophic cardiomyopathy, Veterinary World, 15(2): 502-508.

Abstract

Background and Aim: Hypertrophic cardiomyopathy (HCM) is a common heart problem that affects many cats. Although cats with HCM are symptomatic, some die suddenly or develop congestive heart failure. Therefore, this study aimed to estimate the prevalence of myosin-binding protein C3 (MYBPC3), A31P, and A74T polymorphisms in Maine Coon cats to assess risk factors for diagnosing HCM in cats.

Materials and Methods: Forty-nine Maine Coon cats of at least 10 months of age were enrolled in this study. First, clinical parameters, such as heart rate, systolic blood pressure, and echocardiography, were evaluated. Then, polymerase chain reaction, followed by DNA sequencing, was conducted using specific primers for amino acid substitutions caused by genetic variants of MYBPC3-A31P and -A74T polymorphisms.

Results: Investigations showed that the prevalence of MYBPC3-A31P and -A74T mutations in this study was 16.33% and 24.45%, respectively. Moreover, HCM in cats with MYBPC3-A31P and A74T mutations increased with age, body weight, high heart rate, and prolonged isovolumic relaxation time.

Conclusion: Therefore, we propose that Maine Coon cats develop HCM due to multiple genetic factors and underlying clinical characteristics in individual cats. Furthermore, relaxation time assessments can be a sensitive technique for HCM screening during its preclinical phase and can help identify the risk of developing HCM. However, further studies are warranted to evaluate the effect of MYBPC3 mutations on the phenotypic expression of HCM.

Keywords: feline, hypertrophic cardiomyopathy, mutation, myosin-binding protein.