Vet World Vol.11 February-2018 Article-14
Research Article
Veterinary World, 11(2): 177-180
https://doi.org/10.14202/vetworld.2018.177-180
The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene
2. Undergraduate student of Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Background and Aim: The aim of this study was to analyze the effect of moderate exercise on the elevation of Bax/Bcl-2 ratio.
Materials and Methods: Eighteen Mus musculus strain Swiss Webster (Balb/c) were divided into three groups (n=6). K1 and K2 had contact with water 3 times/week for 12 weeks, while the members of the K3 group swam 3 times/week for 12 weeks while carrying load weighed 3% of their body weight. After 5 weeks, they were induced with 0.04 ml oleum olivarum (K1), 0.08 mg benzopyrene/0.04 ml oleum olivarum (K2, K3) 3 times/week for 4 weeks. Immunohistochemistry assays were used to determine the ratio of Bax/Bcl-2 expression. The results were analyzed using an independent t-test.
Results: The Bax/Bcl-2 ratio increased significantly in K3 compared to K2 (p=0.00).
Conclusion: Moderate exercise could increase the Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene. Keywords: Bax/Bcl-2 ratio, benzopyrene, moderate exercise, oral squamous carcinoma.
Keywords: Bax/Bcl-2 ratio, benzopyrene, moderate exercise, oral squamous carcinoma.
How to cite this article: Irmawati A, Jasmin N, Sidarningsih (2018) The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene, Veterinary World, 11(2): 177-180.
Received: 11-10-2017 Accepted: 08-01-2018 Published online: 13-02-2018
Corresponding author: Anis Irmawati E-mail: anis-m@fkg.unair.ac.id
DOI: 10.14202/vetworld.2018.177-180
Copyright: Irmawati, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.