Vet World   Vol.11   February-2018  Article-26

Effect of levamisole, Vitamin E, and selenium against aflatoxicosis in broilers chicken

Background and Aim: The experiment was conducted to determine of levamisole (0.2 ml/kg-BW), Vitamin E (80 mg)+selenium (1.6 mg), and aflatoxin (B1) (positive control) compared with group without aflatoxin (negative control) on some liver enzymes (aspartate transaminase [AST] and alanine transaminase [ALT]), as well as to study the histopathological changes.

Materials and Methods: The experiment included (200) 1-day-old broilers Ross 308 (Turkey source) mixed sexes. They were divided into four equal groups (50 chicks each group). The experimental period was extended to 35 days.

Results: The results revealed that the levels of liver enzymes (ALT and AST) of all groups at 35 days were significantly (p<0.05) higher than the negative control. Furthermore, the result of histopathological changes in thymus and Harderian gland in different ages of group Vitamin E+selenium showed a reduction in the depletion of the cortex as well as lessening of congestion and hemorrhage and necrosis also decreasing in inflammatory cells in the thymus and Harderian gland.

Conclusion: The study confirmed the protective effect of Vitamin E and levamisole by reducing harmful impacts of aflatoxin through their antioxidant effect as they improved the liver enzymes and histopathological changes due to the toxin. Keywords: aflatoxin, aspartate transaminase, alanine transaminase, broiler, levamisole, Vitamin E and selenium.

Keywords: aflatoxin, aspartate transaminase, alanine transaminase, broiler, levamisole, Vitamin E and selenium.

How to cite this article: Amjed H. Ulaiwi (2018) Effect of levamisole, Vitamin E, and selenium against aflatoxicosis in broilers chicken, Veterinary World, 11(2): 248-253.

Received: 27-10-2017  Accepted: 29-01-2018     Published online: 24-02-2018

Corresponding author: Amjed H. Ulaiwi   E-mail: amjed_alseidy@yahoo.com

DOI: 10.14202/vetworld.2018.248-253

Copyright: Amjed H. Ulaiwi, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.