Vet World Vol.11 May-2018 Article-15
Research Article
Veterinary World, 11(5): 674-680
https://doi.org/10.14202/vetworld.2018.674-680
Use of goat interleukin-6, cortisol, and some biomarkers to evaluate clinical suitability of two routes of ascorbic acid administration in transportation stress
2. Department of Veterinary Medicine, University of Ibadan, Nigeria.
3. Department of Veterinary Microbiology, University of Ilorin, Nigeria.
4. Institute of Food Security, Environmental Resources and Agricultural Research, IFSERAR, Federal University of Agriculture, Abeokuta, Nigeria.
5. Department of Veterinary Physiology and Biochemistry, University of Ilorin, Nigeria.
Background and Aim: The study determined the effect of ascorbic acid (administered orally and intramuscularly) in short-term transportation stress.
Materials and Methods: Twenty-four apparently healthy Kalahari goats were grouped into four groups (A, B, C, and D) of 6 animals each: Group A - untreated and unexposed to stress; Group B - treated with 200 mg/kg Vitamin C orally and exposed to 2 h transportation stress; Group C - treated with Vitamin C 200 mg/kg intramuscularly and exposed to 2 h transportation stress; and Group D - untreated and exposed to 2 h transportation stress. The animals were stocked using standards stipulated by the Nigerian Animal Disease Control Act and transported at 40 km/h. Cortisol and interleukin-6 (IL-6) were assayed using quantitative sandwich ELISA. Classical stress hematological parameters and antioxidative stress markers such as glutathione s-transferase, superoxide dismutase, and malondialdehyde were determined. Heart rate variability (HRV) was also assessed.
Results: The route of ascorbic acid administration did not influence the expression of IL-6, and changes in cortisol surge, antioxidative stress markers, and other hematological parameters in Kalahari goats though Group C goats showed higher HRV values (p<0.05) than others. This gives credence to the enhanced cardiac responsiveness and stress survivability in Kalahari goats.
Conclusion: Both routes could be used in the administration of ascorbic acid. Kalahari goats exposed to short-term stress; however, the intramuscular route had better heart variability and thus improved the survivability of the animals. Keywords: ascorbic acid, intramuscular, oral, Kalahari goats, stress.
Keywords: ascorbic acid, intramuscular, oral, Kalahari goats, stress.
How to cite this article: Biobaku KT, Omobowale TO, Akeem AO, Aremu A, Okwelum N, Adah AS (2018) Use of goat interleukin-6, cortisol, and some biomarkers to evaluate clinical suitability of two routes of ascorbic acid administration in transportation stress, Veterinary World, 11(5): 674-680.
Received: 19-01-2018 Accepted: 20-04-2018 Published online: 22-05-2018
Corresponding author: Ahmed O. Akeem E-mail: ahmed.oa@unilorin.edu.ng
DOI: 10.14202/vetworld.2018.674-680
Copyright: Biobaku, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.