Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review

Vet World Vol.11 November-2018 Article-15

Review Article

Veterinary World, 11(11): 1618-1623

https://doi.org/10.14202/vetworld.2018.1618-1623

Akshay Kumar¹, Abhishek Kumar Mishra², Dilip Kumar Swain³, Vijay Singh¹, Sarvajeet Yadav³, and Atul Saxena¹

1. Department of Gynaecology and Obstetrics, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura, Uttar Pradesh, India.
2. College of Biotechnology, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura, Uttar Pradesh, India.
3. Department of Physiology, College of Veterinary Sciences and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan, Mathura, Uttar Pradesh, India.

Background and Aim: Flagellar navigation along the genital tract of male and female in spermatozoa is accomplished through a number of biological, physiological, biochemical, and electrophysiological alterations in spermatozoa. These alterations are highly precise, dynamic, and regulated through a number of ion channels along with their associated pathways. Beating of flagella along with intracellular metabolism of spermatozoa is associated with fluxing of Ca++ as well as release of Ca++ from different sources. Calcium fluxing through the spermatozoa is mediated through sperm-specific calcium channel and also through transient receptor potential (TRP) channels which are diversified multifamily of ion channels which are activated through a number of extracellular agents such as pH, temperature, chemicals, and pathogens. Research has shown the dynamic role of TRP channels in regulating sperm functions such as sperm chemotaxis, rheotaxis, thermotaxis, and eventually fertilization. Diversified forms of TRP and their involvement in regulation of sperm function opens new horizons of understanding of the sperm function and, in specific, issues related to infertility. This mini-review is an attempt to draw some insights into the action of TRP channels in regulating sperm fertility competence through both calcium-dependent and calcium-independent mechanisms.

Keywords: acrosome reaction, calcium, capacitation, fertilization, motility, pH, sperm, temperature, transient receptor potential.

How to cite this article: Kumar A, Mishra AK, Swain DK, Singh V, Yadav S, Saxena A (2018) Role of transient receptor potential channels in regulating spermatozoa functions: A mini-review, Veterinary World, 11(11): 1618-1623.

Received: 16-07-2018 Accepted: 08-10-2018 Published online: 23-11-2018

Corresponding author: Dilip Kumar Swain E-mail: dilip_swain@yahoo.com

DOI: 10.14202/vetworld.2018.1618-1623

Copyright: Kumar, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.