The role of E3 ubiquitin ligase seven in absentia homolog in the innate immune system: An overview

Vet World Vol.11 November-2018 Article-4

Review Article

Veterinary World, 11(11): 1551-1557

https://doi.org/10.14202/vetworld.2018.1551-1557

Ferbian Milas Siswanto¹, I. Made Jawi², and Bambang Hadi Kartiko¹

1. Department of Biochemistry, Faculty of Health Science and Technology, Dhyana Pura University, Badung, Indonesia.
2. Department of Pharmacology, Faculty of Medicine, Udayana University, Denpasar, Indonesia.

Background and Aim: The innate immune system has been considered as an ancient system and less important than the adaptive immune system. However, the interest in innate immunity has grown significantly in the past few years marked by the identification of Toll-like receptors, a member of pattern recognition receptors (PRRs). The PRRs are crucial for the identification of self- and non-self-antigen and play a role in the initiation of signaling events that activate the effective immune response. These sensor signals through interweaving signaling cascades which result in the production of interferons and cytokines as the effector of immune system. Ubiquitin and ubiquitin-like modifiers (UBLs) actively mediate the rapid and versatile regulatory processes that initiate the activation of the innate immune system cascade. The seven in absentia homolog (SIAH) is a potent RING finger E3 ubiquitin ligase that is known to involve in several stress responses, including hypoxia, oxidative stress, DNA damage stress, and inflammation. In this review, the role of SIAH will be discussed as an E3 ubiquitin ligase on the regulation of innate immune.

Keywords: E3 ligase, innate immunity, regulation, seven in absentia homolog.

How to cite this article: Siswanto FM, Jawi IM, Kartiko BH (2018) The role of E3 ubiquitin ligase seven in absentia homolog in the innate immune system: An overview, Veterinary World, 11(11): 1551-1557.

Received: 24-07-2018 Accepted: 03-10-2018 Published online: 07-11-2018

Corresponding author: Ferbian Milas Siswanto E-mail: ferbianms@undhirabali.ac.id

DOI: 10.14202/vetworld.2018.1551-1557

Copyright: Siswanto, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.