Vet World   Vol.13   February-2020  Article-3

Influence of interferon-based drugs on immunological indices in specific prevention

Background and Aim: The research aimed to study the effect of interferon (IFN)-based drugs on the behavior of immunological parameters in calves during the specific prevention of associative infections.

Materials and Methods: The object of research was 45 black motley cows and their calves from birth to 2 months of life. Serum and colostrum samples were screened for antibodies against Rotavirus, diarrhea, and coronavirus using serological methods. The testing was performed before vaccination, 40 days before calving, 20 days before calving, and before calving. Colostrum samples were taken during the first milk yield. Serum samples from calves were drawn before colostrum feeding as well as at 7, 14, and 21 days, and 1 and 2 months of age. To measure the level of immunoglobulins A, M, and G, additional serum samples were collected from calves at 25, 35, 65, and 75 days after birth.

Results: Giving pregnant cows, an IFN-based drug at a dose of 1 ml/kg 48 h before vaccination results in the development and accumulation of antibodies to Rotavirus, coronavirus, and viral diarrhea (VD) in the colostrum, with a titer of 7.6±0.3 log2, 5.8±0.34 log2, and 4.4±0.18 log2, respectively. It indicates an increase in the antigenic activity of the multivalent vaccine.

Conclusion: IFN-based drugs enhance the protective effect of vaccination against associative infections in the newborn calves. They stimulate a rise in the titer of antibodies to Rotavirus, coronavirus, VD, and mucosal disease complex as well as an increase in immunoglobulins A, M, and G. Keywords: antibody titer, coronavirus, immunoglobulins A, M, and G, interferon, Rotavirus, vaccinations.

Keywords: antibody titer, coronavirus, immunoglobulins A, M, and G, interferon, Rotavirus, vaccinations.

How to cite this article: Andreeva A, Nikolaeva O, Altynbekov O, Galieva C, Ilina K (2020) Influence of interferon-based drugs on immunological indices in specific prevention, Veterinary World, 13(2): 238-244.

Received: 20-08-2019  Accepted: 27-12-2019     Published online: 10-02-2020

Corresponding author: Alfia Andreeva   E-mail: alandreeva98@yahoo.com

DOI: 10.14202/vetworld.2020.238-244

Copyright: Andreeva, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.