Vet World   Vol.13   July-2020  Article-11

Preliminary screening of the possible protective effect of Moroccan propolis against chromium-induced nephrotoxicity in animal model

Background and Aim: Hexavalent chromium (Cr (VI)) compounds have been shown to induce nephrotoxicity associated with oxidative stress in humans and animals. The aim of the present study was to investigate the nephroprotective effect of bee propolis, as highly antioxidant natural product, in vivo using an animal model.

Materials and Methods: First of all, total phenol and flavonoid contents of propolis sample were estimated in vitro. Afterward, to study the protective effect of propolis on renal damages caused by an injection of a single dose of potassium dichromate (15 mg/kg b.wt), 24 male Wister rats were divided into test and control groups. Propolis treatment was performed by oral gavage of 100 mg/kg b.wt/day, while the control groups received water instead. The 24 h urine was collected and blood samples were withdrawn before and after each treatment for further analysis.

Results: Propolis revealed to be rich in polyphenols and flavonoids. Chromate provoked a nephrotoxic effect expressed by a drastic decrease in glomerular filtration assessed by creatinine clearance. However, the administration of propolis attenuated the renal damages induced by the chromate. This attenuation can be seen by the increase of creatinine clearance when comparing propolis treated group to the non-treated group.

Conclusion: Propolis showed a protective potential against chromate-induced nephrotoxicity through the amelioration of chromate's toxic effects. It might be concluded that propolis could be effective as chemoprotectant in the management of potassium dichromate-induced nephrotoxicity. Keywords: antioxidant, chromium, phenols, propolis, renal damage.

Keywords: antioxidant, chromium, phenols, propolis, renal damage.

How to cite this article: EL-Guendouz S, Zizi S, Elamine Y, Lyoussi B (2020) Preliminary screening of the possible protective effect of Moroccan propolis against chromium-induced nephrotoxicity in animal model, Veterinary World, 13(7): 1327-1333.

Received: 12-11-2019  Accepted: 19-05-2020     Published online: 14-07-2020

Corresponding author: Badiaa Lyoussi   E-mail: lyoussi@gmail.com

DOI: 10.14202/vetworld.2020.1327-1333

Copyright: EL-Guendouz, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.