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Research Article | 22 Sep 2026

Global epidemiology and antimicrobial resistance of extended-spectrum β-lactamase-producing Vibrio species: A One Health systematic review and meta-analysis

Varangkana Thaotumpitak1 ORCID , Saran Anuntawirun2, Nawaphorn Roongrojmongkhon2 ORCID , Manoj Tukaram Kamble3 ORCID , and Saharuetai Jeamsripong2,4 ORCID Show more
VETERINARY WORLD | Article No. 23 | pg no. 4210-4229 | Vol. 19, Issue 9 | DOI: 10.14202/vetworld.2026.4210-4229
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ABSTRACT

                      
Background and Aim: Vibrio spp. are important aquatic bacteria associated with human disease, aquaculture losses, seafood safety, and environmental reservoirs of antimicrobial resistance (AMR). The emergence of extended-spectrum β-lactamase (ESBL)-producing Vibrio spp. may compromise β-lactam therapy and facilitate resistance dissemination across interconnected One Health sectors. This systematic review and meta-analysis aimed to determine the prevalence of Vibrio spp. and ESBL-producing isolates and characterize their phenotypic AMR, multidrug resistance (MDR), and resistance-associated genes across human, animal, and environmental sources.
Materials and Methods: Literature published from 2012 to 2024 was systematically retrieved from PubMed, Scopus, and Google Scholar following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The protocol was registered in the International Prospective Register of Systematic Reviews (CRD420251114318). Pooled prevalence estimates were calculated using random-effects models, heterogeneity was assessed using Cochran’s Q and I² statistics, and subgroup analyses were conducted by continent and Vibrio species. Risk-of-bias was evaluated using the Joanna Briggs Institute checklist.
Results: Of 1,120 records identified, 31 studies were included, representing 4,486 samples and 3,242 Vibrio isolates, predominantly from Asia and Africa. The pooled prevalence of Vibrio spp. was 48.3% (95% confidence interval [CI]: 34.0–62.7%; I² = 99.37%), whereas ESBL-producing Vibrio spp. had a pooled prevalence of 19.4% (95% CI: 3.2–43.7%; I² = 95.87%). Ampicillin showed the highest pooled β-lactam resistance at 73.6% (95% CI: 58.4–86.4%). The overall pooled MDR prevalence was 31.5% (95% CI: 6.1–64.7%). Resistance varied substantially among Vibrio species, including marked resistance to third-generation cephalosporins in selected species. Among resistance determinants, blaTEM was predominant, with a pooled prevalence of 33.8%, while carbapenemase-associated blaVIM and blaIMP were also detected. Considerable between-study heterogeneity was observed for most outcomes.
Conclusion: ESBL-producing and multidrug-resistant Vibrio spp. occur across human, animal, and environmental sources, demonstrating substantial geographical and species-specific variation. The high β-lactam resistance and detection of clinically important resistance determinants emphasize the need for harmonized antimicrobial susceptibility testing, molecular surveillance, and integrated One Health monitoring to limit the emergence and dissemination of resistant Vibrio spp.
                      
Keywords: antimicrobial resistance, aquatic environment, extended-spectrum β-lactamase, meta-analysis, multidrug resistance, One Health, systematic review, Vibrio species.