Vet World   Vol.13   May-2020  Article-19

Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice

Background and Aim: This study examines the effect of alpha-lipoic acid (ALA) on sodium valproate-induced liver injury through histological features of mice liver tissue.

Materials and Methods: Mice were divided into three groups; (1) vehicle group, (2) sodium valproate group, and (3) sodium valproate-ALA group. The vehicle group was injected with saline intraperitoneal (i.p.) for 28 days. The sodium valproate group was injected with sodium valproate 300 mg/kg, i.p. daily for 2 weeks, after which the vehicle was administered daily until day 28. The sodium valproate-ALA group was injected with sodium valproate 300 mg/kg daily for 2 weeks before the administration of ALA 100 mg/kg i.p. until day 28. The mice were euthanized, and the liver was extracted for histopathological examination.

Results: Histopathological examination of the liver section of the vehicle group showed a normal structure of the liver. Two weeks after the administration of sodium valproate, histopathological examination showed an abnormal structure of the liver, with necrotic appearance and inflammatory cells. Moreover, treatment with ALA after the administration of sodium valproate notably ameliorated hepatic histopathological lesions and the liver structure corresponded to a normal liver structure.

Conclusion: ALA ameliorates sodium valproate-induced liver injury in mice. Keywords: alpha-lipoic acid, drug-induced liver injury, histopathological, liver injury, sodium valproate.

Keywords: alpha-lipoic acid, drug-induced liver injury, histopathological, liver injury, sodium valproate.

How to cite this article: Ardianto C, Wardani HA, Nurrahmi N, Rahmadi M, Khotib J (2020) Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice, Veterinary World, 13(5): 963-966.

Received: 19-11-2019  Accepted: 16-04-2020     Published online: 22-05-2020

Corresponding author: Chrismawan Ardianto   E-mail: chrismawan-a@ff.unair.ac.id

DOI: 10.14202/vetworld.2020.963-966

Copyright: Ardianto, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.