Vet World Vol.13 May-2020 Article-9
Research Article
Veterinary World, 13(5): 890-895
https://doi.org/10.14202/vetworld.2020.890-895
Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease
2. Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Egypt (Infectious Diseases).
3. Department of Clinical Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.
4. Department of Animal Medicine, Faculty of Veterinary Medicine, Alexandria University, Egypt.
Background and Aim: Foot-and-mouth disease (FMD) causes huge economic losses in Egypt due to reductions in the production of red meat, milk, and milk by-products and can also lead to myocarditis in young animals. The aim of our study was to evaluate cardiac biomarkers, in particular cardiac troponin I (cTnI), and to reveal the relations of cardiac biomarkers with poor survival in FMD-infected Egyptian buffalo calves.
Materials and Methods: Forty-two Egyptian buffalo calves were included in this study. The calves were divided into 12 apparently healthy control calves and 30 calves clinically diagnosed with FMD during a disease outbreak in Menofia and Behera Governorates, Egypt. The diseased calves were divided, according to age, into 13 calves <3 months old and 17 calves between 3 and 6 months old. The animals were examined clinically and subjected to analysis of cardiac biomarkers.
Results: Biochemical analysis revealed significant elevations of cardiac biomarkers, especially creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotransferase (AST), cardiac troponin T (cTnT), and cardiac troponin I (cTnI) in FMD-infected calves in comparison with control calves. There was a significant association between cTnI and poor survival in infected calves.
Conclusion: Cardiac biomarkers could be used as a rapid method for diagnosis of myocarditis induced by FMD in Egyptian buffalo calves. In addition, cTnI is a very sensitive and accurate tool for determining myocardial cell damage in the earlier stages of the disease and a good predictor of poor survival in calves. Keywords: cardiac troponin I, Egyptian buffalo calves, foot-and-mouth disease, myocarditis.
Keywords: cardiac troponin I, Egyptian buffalo calves, foot-and-mouth disease, myocarditis.
How to cite this article: Aly M, Nayel M, Salama A, Ghazy E, Elshahawy I (2020) Cardiac troponin I as a cardiac biomarker has prognostic and predictive value for poor survival in Egyptian buffalo calves with foot-and-mouth disease, Veterinary World, 13(5): 890-895.
Received: 23-12-2019 Accepted: 03-04-2020 Published online: 14-05-2020
Corresponding author: Mahmoud Aly E-mail: allaamvet82@yahoo.com
DOI: 10.14202/vetworld.2020.890-895
Copyright: Aly, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.