Vet World Vol.14 July-2021 Article-7
Review Article
Veterinary World, 14(7): 1774-1783
https://doi.org/10.14202/vetworld.2021.1774-1783
Development of rat metabolic syndrome models: A review
2. Doctoral Programme in Biomedical Science Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
3. Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
4. Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Background and Aim: Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study.
Keywords: high-fat diet, high-fructose diet, high-sucrose diet, metabolic syndrome, rat models.
How to cite this article: Gunawan S, Aulia A, Soetikno V (2021) Development of rat metabolic syndrome models: A review, Veterinary World, 14(7): 1774-1783.
Received: 15-02-2021 Accepted: 27-05-2021 Published online: 07-07-2021
Corresponding author: Shirly Gunawan E-mail: shirlyg@fk.untar.ac.id
DOI: 10.14202/vetworld.2021.1774-1783
Copyright: Gunawan, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.