Vet World Vol.15 July-2022 Article-14
Research Article
Veterinary World, 15(7): 1706-1713
https://doi.org/10.14202/vetworld.2022.1706-1713
Effects of intranasal and intramuscular dexmedetomidine in cats receiving total intravenous propofol anesthesia
2. Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.
3. Tippimarn Veterinary Hospital, Chulabhorn Royal Academy, Nakhon Ratchasima, Thailand.
Background and Aim: The efficacy of intranasal (IN) dexmedetomidine in cats as a premedication remains elusive. Thus, this study aimed to compare the perioperative and sparing effects of IN and intramuscular (IM) dexmedetomidine administration on propofol requirements for anesthetic induction in cats.
Materials and Methods: This study randomly assigned 16 cats into two groups of IN or IM dexmedetomidine at 20 μg/kg. Sedation scores and side effects were recorded at time points of 0, 5, 10, 15, and 20 min after the dexmedetomidine administration. Anesthesia was induced with intravenous (IV) 1% propofol by titrating a bolus of 2 mg every 45 s and the total dose of the administered IV propofol to achieve endotracheal intubation was recorded.
Results: Cats receiving IM dexmedetomidine were significantly associated with higher sedation scores. All cats were sedated at 20 min after premedication; however, the average composite sedation scores in the IN group were significantly lower than those in the IM group during premedication. Pre-operative side effects, including vomiting, were more frequently observed in the IN group (5 cats, 62.5%) than in the IM group (3 cats, 37.5%; p < 0.05). Higher body temperature (>1°F compared to baseline) was more frequently observed in the IN group (6 cats, 75.0%) than in the IM group (1 cat, 12.5%; p < 0.05). The dosage of required propofol in the IN group was significantly higher (1.1 ± 0.3 mg/kg) than that in the IM group (0.7 ± 0.2 mg/kg; p < 0.05). The duration of general anesthesia was comparable between the groups.
Conclusion: IN dexmedetomidine produces moderate sedation and cats may have side effects, including vomiting and higher body temperature. Higher sparing effects of propofol were identified in the IM group compared with the IN group. Nonetheless, IN administration of dexmedetomidine provides a noninvasive alternative to the IM route. Keywords: cats, dexmedetomidine, intranasal, propofol, sedative.
Keywords: cats, dexmedetomidine, intranasal, propofol, sedative.
How to cite this article: Hommuang K, Sattasathuchana P, Thengchaisri N (2022) Effects of intranasal and intramuscular dexmedetomidine in cats receiving total intravenous propofol anesthesia, Veterinary World, 15(7): 1706–1713.
Received: 02-03-2022 Accepted: 27-05-2022 Published online: 20-07-2022
Corresponding author: Naris Thengchaisri E-mail: ajnaris@yahoo.com
DOI: 10.14202/vetworld.2022.1706-1713
Copyright: Hommuang, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.