Implications of sperm heat shock protein 70-2 in bull fertility

Vet World Vol.15 June-2022 Article-8

Review Article

Veterinary World, 15(6): 1456-1466

https://doi.org/10.14202/vetworld.2022.1456-1466

Zulfi Nur Amrina Rosyada¹, Mokhamad Fakhrul Ulum^1,2, Ligaya I. T. A. Tumbelaka^1,2, Dedy Duryadi Solihin³, Bambang Purwantara^1,2, and Erdogan Memili⁴

1. Reproductive Biology Study Program, Postgraduate School, IPB University, 16680, Bogor, Indonesia.
2. Department of Veterinary Clinic, Reproduction and Pathology, School of Veterinary Medicine and Biomedical Sciences, IPB University, 16680, Bogor, Indonesia.
3. Department of Biology, Faculty of Science, IPB University, 16680, Bogor, Indonesia.
4. Agricultural Research Center, College of Agriculture and Human Sciences Prairie View A&M University, Prairie View, TX, USA.

Background and Aim: Heat shock protein 70 (HSP70) is one of the most abundant chaperone proteins. Their function is well documented in facilitating the protein synthesis, translocation, de novo folding, and ordering of multiprotein complexes. HSP70 in bovine consists of four genes: HSP70-1, HSP70-2, HSP70-3, and HSP70-4. HSP70-2 was found to be involved in fertility. Current knowledge implicates HSP70-2 in sperm quality, sperm capacitation, sperm–egg recognition, and fertilization essential for bull reproduction. HSP70-2 is also involved in the biological processes of spermatogenesis, as it protects cells from the effects of apoptosis and oxidative stress. Fertilization success is not only determined by the amount of sperm found in the female reproductive tract but also by the functional ability of the sperm. However, subfertility is more likely to be associated with changes in sperm molecular dynamics not detectable using conventional methods. As such, molecular analyses and omics methods have been developed to monitor crucial aspects of sperm molecular morphology that are important for sperm functions, which are the objectives of this review.

Keywords: fertility, heat shock protein, protective, semen quality, stress.

How to cite this article: Rosyada ZNA, Ulum MF, Tumbelaka LITA, Solihin DD, Purwantara B, Memili E (2022) Implications of sperm heat shock protein 70-2 in bull fertility, Veterinary World, 15(6): 1456-1466.

Received: 16-01-2022 Accepted: 22-04-2022 Published online: 13-06-2022

Corresponding author: Bambang Purwantara E-mail: purwantara@apps.ipb.ac.id

DOI: 10.14202/vetworld.2022.1456-1466

Copyright: Rosyada ZNA, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.