Vet World Vol.16 April-2023 Article-17
Research Article
Veterinary World, 16(4): 792-798
https://doi.org/10.14202/vetworld.2023.792-798
Clinical field trial of parenteral amoxicillin for the treatment of clinical and subclinical mastitis in smallholder dairy farms in the upper region of Northern Thailand
2. Department of Food Animal Clinics , Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand.
3. Research Center of Producing and Development of Products and Innovations for Animal Health, Chiang Mai University, Chiang Mai 50100, Thailand.
Background and Aim: Mastitis, primarily caused by intramammary bacterial infection, is the most expensive disease in the global dairy industry due to its negative impact on milk composition and manufacturing properties. This study aimed to evaluate the efficacy of parenteral amoxicillin in the treatment of clinical and subclinical mastitis in smallholder dairy farms in Northern Thailand.
Materials and Methods: A total of 51 cows with clinical and subclinical mastitis from dairy cooperatives in Lamphun and Chiang Mai provinces, Northern Thailand, were enrolled in this study. Conventional bacteriological procedures were applied to identify the causative bacteria in milk samples from these cows before and 7 days after treatment, and antibiotic susceptibility tests were conducted using the disk diffusion method for all bacteria isolated before treatment. All cows with mastitis were administered 15 mg/kg of amoxicillin (LONGAMOX®, Syva Laboratories SA, Spain) intramuscularly every other day for 3 days.
Results: Environmental streptococcal bacteria (Streptococcus uberis and Streptococcus spp.) were commonly isolated from infected quarters and were highly susceptible to amoxicillin (100%). The clinical efficacy of amoxicillin treatment for clinical mastitis cases was 80.43%, and the bacteriological efficacy was 47.82%, with opportunistic staphylococcal bacteria (coagulase-negative staphylococci) and contagious streptococcal bacteria (Streptococcus agalactiae) being the most sensitive microorganisms (100%). In subclinical mastitis cases, the bacteriological efficacy of parenteral amoxicillin was 70.45%, with environmental streptococcal bacteria (S. uberis) being the most (100%) sensitive microorganisms.
Conclusion: Amoxicillin is highly efficacious and can be used to treat clinical and subclinical mastitis in dairy cows, particularly mastitis caused by environmental Streptococcus spp. These findings could be used to guide treatment regimens in veterinary practice in smallholder dairy farms in Thailand. Keywords: bacteriological cure, clinical cure, dairy cow, mastitis, parenteral amoxicillin.
Keywords: bacteriological cure, clinical cure, dairy cow, mastitis, parenteral amoxicillin.
How to cite this article: Pangprasit N, Srithanasuwan A, Intanon M, Suriyasathaporn W, and Chaisri W (2023) Clinical field trial of parenteral amoxicillin for the treatment of clinical and subclinical mastitis in smallholder dairy farms in the upper region of Northern Thailand, Veterinary World, 16(4): 792-798.
Received: 15-11-2022 Accepted: 09-03-2023 Published online: 19-04-2023
Corresponding author: E-mail: wasana.ch@cmu.ac.th/wasana_kosa@hotmail.com
DOI: 10.14202/vetworld.2023.792-798
Copyright: Pangprasit, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.