Comparative effects of dietary zinc nanoparticle and conventional zinc supplementation on broiler chickens: A meta-analysis

Vet World Vol.17 August-2024 Article - 10

Research Article

Veterinary World, 17(8): 1733-1747

https://doi.org/10.14202/vetworld.2024.1733-1747

Cecep Hidayat¹, Sadarman Sadarman^2,3, Danung Nur Adli^3,4, Ridho Kurniawan Rusli^3,5, Bachtar Bakrie¹, Simon Petrus Ginting¹, Santiananda Arta Asmarasari¹, Bram Brahmantiyo¹, Arif Darmawan^3,6, Hasnelly Zainal¹, Achmad Fanindi¹, Supardi Rusdiana¹, Iwan Herdiawan¹, Endang Sutedi¹, Yulianri Rizki Yanza^3,7, and Anuraga Jayanegara^3,6

1. Research Center for Animal Husbandry, Research Organization for Agriculture and Food, National Research and Innovation Agency of Indonesia, Cibinong Science Center, Jalan Raya Jakarta-Bogor, Cibinong, Bogor 16915, West Java, Indonesia.
2. Department of Animal Science, Faculty of Agriculture and Animal Science, Universitas Islam Negeri Sultan Syarif Kasim Riau, Pekanbaru 28293, Indonesia.
3. Animal Feed and Nutrition Modelling Research Group, Faculty of Animal Science, IPB University, Bogor 16680, Indonesia.
4. Department of Feed and Animal Nutrition, Faculty of Animal Science, Universitas Brawijaya, Malang, Indonesia.
5. Department of Nutrition and Feed Technology, Faculty of Animal Science, Universitas Andalas, Padang, 25175, Indonesia.
6. Department of Nutrition and Feed Technology, Faculty of Animal Science, IPB University, Bogor 16680, Indonesia.
7. Department of Animal Nutrition and Feed Technology, Faculty of Animal Husbandry, Padjadjaran University, Jl. Raya Bandung Sumedang KM 21, Jatinangor, Sumedang, 45363, Indonesia.

Background and Aim: Zinc (Zn) is important for various physiological processes in broiler chickens, including protein and carbohydrate metabolism, growth, and reproduction. The gastrointestinal absorption of Zn in broiler chickens was notably low. One approach that has been explored for enhancing the bioavailability of Zn is the development of Zn nanoparticles (NPs). Zn is required for various physiological processes in broiler chickens, including protein and carbohydrate metabolism, growth, and reproduction. Therefore, this study aimed to assess the impact of conventional Zn and Zn NPs on broiler chickens using a meta-analysis methodology.

Materials and Methods: A database was built from published literature to evaluate the effects of the addition of Zn NPs and conventional Zn on broiler chicken responses, including the following parameters: production performance; carcass cuts; visceral organ weight; lymphoid organ weight; nutrient digestibility; intestinal villi; mineral Zn, calcium, and phosphorus concentrations; hematology; blood parameters; immunoglobulin; and intestinal bacterial population. Various scientific platforms, including Scopus, Web of Science, PubMed Central, and Google Scholar, were used to search for peer-reviewed articles. A database was created from 25 studies that met the inclusion criteria. The data were then processed for a meta-analysis using a mixed-model methodology. Different types of Zn (NPs versus conventional) were considered fixed effects, different studies were treated as random effects, and p-values were used as model statistics.

Results: Across the parameters observed in this study, the use of Zn NPs was more efficient in Zn utilization than conventional Zn, as evidenced by the average dose of Zn NPs being much lower than that of conventional Zn (79.44 vs. 242.76 mg/kg) yet providing similar (p > 0.05) or even significantly better effects (p < 0.05) compared to conventional Zn usage.

Conclusion: This investigation revealed the beneficial influence of Zn NPs in broiler chickens compared to the conventional utilization of Zn through an all-encompassing meta-analysis. Moreover, Zn NPs have proven to be more effective in Zn utilization when juxtaposed with conventional Zn, as demonstrated by the significantly lower quantity of Zn NPs administered compared to conventional Zn, while yielding comparable or even superior outcomes compared to the traditional utilization of Zn. A limitation of this study is that the Zn NPs used were sourced from inorganic Zn NPs. Therefore, future research should focus on evaluating the efficiency of organic Zn NPs in broiler chicken feed.

Keywords: broiler chicken, conventional zinc, performance, welfare indices, zinc nanoparticles.

How to cite this article: Hidayat C, Sadarman S, Adli DN, Rusli RK, Bakrie B, Ginting SP, Asmarasari SA, Brahmantiyo B, Darmawan A, Zainal H, Fanindi A, Rusdiana S, Herdiawan I, Sutedi E, Yanza YR, and Jayanegara A (2024) Comparative effects of dietary zinc nanoparticle and conventional zinc supplementation on broiler chickens: A meta-analysis, Veterinary World, 17(8): 1733-1747.

Received: 2024-04-10 Accepted: 2024-07-12 Published online: 2024-08-04

Corresponding author: Cecep Hidayat E-mail: hidayat_c2p@yahoo.com

DOI: 10.14202/vetworld.2024.1733-1747

Copyright: Hidayat, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.