Vet World Vol.17 August-2024 Article - 24
Research Article
Veterinary World, 17(8): 1864-1871
https://doi.org/10.14202/vetworld.2024.1864-1871
Influence of the Saccharomyces cerevisiae-based probiotic complex on gut microbiota, serum biochemistry, and circulating trace element and mineral levels in lactating dairy cows
2. Scientific-Educational Center “Biological Systems and Nanotechnologies”, Orenburg State University, Orenburg, Russia, 460018.
3. Center for Bioelementology and Human Ecology, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, 119991.
4. Laboratory of Microbial Persistence and Symbiosis, Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, Orenburg, Russia, 460000.
Background and Aim: The existing data demonstrate that gut microbiota is involved in regulating mineral metabolism in cattle, although the data are quite contradictory. The study aimed to evaluate Saccharomyces cerevisiae-based probiotic’s effects on gut microbiota, systemic metabolism, and dairy cows’ essential trace element and mineral body burden.
Materials and Methods: Fifteen cows received a daily supplement of a 50 g S. cerevisiae-based probiotic, fortified with methionine, choline, eugenol, cinnamaldehyde, and Capsicum oleoresin, for a month. 16S metagenomic sequencing was used to evaluate the taxonomic features of fecal microbiota. Serum trace elements and minerals levels were determined through inductively coupled plasma mass spectrometry.
Results: Supplementation with S. cerevisiae-based probiotic complex significantly increased alpha and beta diversity, as well as the abundance of Mediterranea and Clostridium IV within the Bacillota phylum, whereas that of Bacteroidota and specifically unclassified Bacteroidales and unclassified Oscillospiraceae decreased. Following probiotic supplementation with the S. cerevisiae-based complex, gut microbiota modulation led to a significant boost in circulating levels of calcium, copper, selenium, and zinc. Creatinine levels decreased while total cholesterol levels increased within normal limits in the serum analysis.
Conclusion: The observed improvement in trace elements and minerals in dairy cows might be due to changes in intestinal microflora caused by supplementation. Therefore, probiotic supplementation in cattle may be considered a potential tool for improvement of mineral nutrition in cattle. However, the influence of probiotic treatment and modulation of mineral metabolism on milk productivity and overall performance in cattle is yet to be estimated.
Keywords: gut microbiota, minerals, probiotic, Saccharomyces cerevisiae, trace elements.
How to cite this article: Sizova EA, Yausheva EV, Nechitailo KS, Kamirova AM, Ryazanceva KV, Shoshin DE, Skalny AV, and Tinkov AA (2024) Influence of the Saccharomyces cerevisiae-based probiotic complex on gut microbiota, serum biochemistry, and circulating trace element and mineral levels in lactating dairy cows, Veterinary World, 17(8): 1864-1871.
Received: 2024-03-18 Accepted: 2024-07-16 Published online: 2024-08-24
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.1864-1871
Copyright: Sizova, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
