Vet World Vol.17 August-2024 Article - 7
Research Article
Veterinary World, 17(8): 1702-1714
https://doi.org/10.14202/vetworld.2024.1702-1714
A novel study on the quality of life index in canine chronic kidney disease treated with incremental intermittent hemodialysis
2. Department of Teaching Veterinary Clinical Complex, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana - 141 004, Punjab, India.
Background and Aim: In veterinary medicine, health-related quality-of-life index (QOLi) measurements are becoming increasingly important because they are a multifaceted concept that represents not only patients’ physical well-being but also clients’ emotional health. This study assessed QOLi in dogs receiving incremental intermittent hemodialysis (i-IHD) with high- and low-flux dialyzers.
Materials and Methods: Thirty dogs diagnosed with chronic kidney disease (CKD) Stage IV were randomly divided into two groups of 15 dogs each. A high-flux dialyzer was used in Group I, whereas a low-flux dialyzer was used in Group II. i-IHD was performed on days 0, 2, 4, 19, and 34, whereas QOLi evaluation was performed on days 0, 15, 30, and 45.
Results: Both groups exhibited considerable decreases in post-dialysis creatinine, blood urea nitrogen, and phosphorus levels, while Group I experienced notable reductions in post-dialysis triglyceride and cholesterol levels. Dialysis adequacy did not show any significant difference between the clearance rates of high- and low-flux dialyzers. The QOLi assessment showed better post-dialysis scores in all categories except for water balance in Group I, while Group II demonstrated a worsening trend in scores for mental status, appetite, mobility, general health, and pain.
Conclusion: In the first three sessions of i-IHD, dogs with CKD should be treated every other day, and the schedule can be extended by 15 days after that. A high-flux membrane, which effectively decreases triglyceride and cholesterol levels more than a low-flux membrane, warrants consideration for dogs with cardiovascular complications undergoing dialysis. The dialysis-related QOLi aids in clinical decision-making and encourages client engagement.
Keywords: chronic kidney disease, dialysis adequacy, incremental intermittent hemodialysis, quality of life index.
How to cite this article: Singh A, Singh R, Gupta DK, and Singh RS (2024) A novel study on the quality of life index in canine chronic kidney disease treated with incremental intermittent hemodialysis, Veterinary World, 17(8): 1702-1714.
Received: 2024-04-16 Accepted: 2024-07-08 Published online: 2024-08-04
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.1702-1714
Copyright: Singh, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
