Influence of idiopathic epilepsy on blood pressure and electrocardiography in dogs treated with phenobarbital

Vet World Vol.17 February-2024 Article-13

Research Article

Veterinary World, 17(2): 356-360

https://doi.org/10.14202/vetworld.2024.356-360

Yolanda Paim Arruda Trevisan¹, Maria Sabrina de Freitas¹, Maria Natalia de Freitas¹, Jaqueline Konrad¹, Juliano Bortolini², Ana Carolina Schipiura¹, Ana Flávia Borges de Freitas¹, Sarah Szimanski Pazzini³, Arleana do Bom Parto Ferreira de Almeida¹, and Valéria Régia Franco Sousa¹

1. Department of Internal Medicine for Small Animals at the Veterinary Hospital of the Federal University of Mato Grosso. Av. Fernando Corrêa da Costa, nº 2367, Bairro Boa Esperança, Cuiabá, Mato Grosso, CEP: 78060-900, Brazil.
2. Department of Statistics of the Federal University of Mato Grosso. Av. Fernando Corrêa da Costa, nº 2367, Bairro Boa Esperança, Cuiabá, Mato Grosso, CEP: 78060-900, Brazil.
3. Department of Clinical Pathology Laboratory at the Veterinary Hospital of the Federal University of Mato Grosso. Av. Fernando Corrêa da Costa, nº 2367, Bairro Boa Esperança, Cuiabá, Mato Grosso, CEP: 78060-900, Brazil.

Background and Aim: Dogs with idiopathic epilepsy (IE) experience a shortened lifespan, neurobehavioral changes, and an increased risk of comorbidities during the interictal period. There have been several reports of sudden death in humans with epilepsy, suggesting changes in cardiac rhythm secondary to seizures. In veterinary medicine, there are still no such conclusive studies. The present study aimed to evaluate blood pressure values, electrocardiographic findings, and laboratory parameters in dogs with IE treated with phenobarbital and to correlate these findings with possible cardiac alterations.

Materials and Methods: Twenty-one dogs were divided into 11 healthy dogs and 10 idiopathic epileptic dogs for blood analysis, computerized electrocardiogram, and oscillometer-based blood pressure measurement.

Results: QRS complex and S-T interval values differed significantly between groups, but blood pressure values were not significantly different.

Conclusion: IE can occur with alterations in cardiac conduction and is a pathological condition. Keywords: arterial hypertension, cardiac conduction, electrocardiogram, epileptic seizures, hemogasometry, tachycardia.

Keywords: arterial hypertension, cardiac conduction, electrocardiogram, epileptic seizures, hemogasometry, tachycardia.

How to cite this article: Trevisan YPA, de Freitas MS, de Freitas MN, Konrad J, Bortolini J, Schipiura AC, de Freitas AFB, Pazzini SS, de Almeida ADBPF, and Sousa VRF (2024) Influence of idiopathic epilepsy on blood pressure and electrocardiography in dogs treated with phenobarbital, Veterinary World, 17(2): 356-360.

Received: 02-10-2023 Accepted: 18-01-2024 Published online: 15-02-2024

Corresponding author: Yolanda Paim Arruda Trevisan E-mail: yolandapaim@hotmail.com

DOI: 10.14202/vetworld.2024.356-360

Copyright: Trevisan YPA, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.