Vet World Vol.17 June-2024 Article - 27
Research Article
Veterinary World, 17(6): 1405-1412
https://doi.org/10.14202/vetworld.2024.1405-1412
Occurrence of multidrug-resistant Mycobacterium tuberculosis in upper Southern Thailand
2. Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
3. One Health Research Center, Walailak University, Nakhon Si Thammarat 80160, Thailand.
4. School of Allied Health Sciences, Southeast Asia Water Team, World Union for Herbal Drug Discovery, and Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, Thailand.
5. CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
6. Center of Excellence in Innovation of Essential Oil and Bioactive Compounds, Walailak University, Nakhon Si Thammarat, Thailand.
Background and Aim: Mycobacterium tuberculosis causes global concern with tuberculosis (TB). Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) pose additional challenges, as they resist multiple first-line drugs. This study investigated the occurrence of TB, antibiotic resistance due to inhA and katG gene mutations, and multidrug resistance in M. tuberculosis during fiscal years 2020–2022.
Materials and Methods: Samples were gathered from hospitals in seven provinces of upper Southern Thailand. The study investigated the correlation between inhA and katG gene mutations in M. tuberculosis and the development of antimicrobial resistance and isoniazid resistance.
Results: A total of 19,186 samples were sent to the Office of Disease Prevention and Control Region 11st, Nakhon Si Thammarat, Thailand. The results showed that 51% of the samples were obtained from patients located in Nakhon Si Thammarat, followed by Surat Thani provinces. Regarding the spatial distribution of TB-infected cases, the incidence of TB was high in the province, which has a moderate to high population density. The highest average occurrence of TB in this study was found in Phuket province (9.75/100,000 risk person-year). The detected isoniazid resistance was 394, 255, and 179 cases in 2020, 2021, and 2022, respectively. A total of 99 isolates were MDR, whereas four isolates were XDR. The antimicrobial resistance associated with the inhA mutation was 192, 142, and 105 isolates, respectively, whereas the resistance associated with the katG mutation was 249, 182, and 120 cases in 2020, 2021, and 2022, respectively.
Conclusion: These findings contribute to the understanding of the occurrence of antibiotic-resistant TB that could lead to use as data for preventing MDR-TB.
Keywords: inhA and katG genes, isoniazid, multi-drug resistance, Mycobacterium tuberculosis, upper Southern of Thailand.
How to cite this article: Karaipoom P, Saengsawang P, Bromnavej A, Sangsong S, Waseewiwat P, Bunsanong B, Nissapatorn V, de Lourdes Pereira M, and Mitsuwan W (2024) Occurrence of multidrug-resistant Mycobacterium tuberculosis in upper Southern Thailand, Veterinary World, 17(6): 1405–1412.
Received: 2024-03-01 Accepted: 2024-06-04 Published online: 2024-06-28
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.1405-1412
Copyright: Karaipoom, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
