Neuroprotective effects of Paederia foetida Linn. on scopolamine-induced cognitive impairment in rats

Vet World Vol.17 September-2024 Article - 3

Research Article

Veterinary World, 17(9): 1972-1982

https://doi.org/10.14202/vetworld.2024.1972-1982

Narawut Pakaprot¹, Tanaporn Khamphaya², Pattamaporn Kwankaew³, Sarawut Ninsuwan³, Sutida Laisunthad³, Kotchaporn Thonoi³, and Saruda Kuraeiad^3,4

1. Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Srisavarindhira Bldg., 13th Floor, Wanglang Road, Siriraj Subdistrict, Bangkoknoi District, Bangkok, 10700, Thailand.
2. Department of Occupational Health and Safety, School of Public Health, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
3. Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
4. Research Center in Tropical Pathobiology, Walailak University, Nakhon Si Thammarat, 80160, Thailand

Background and Aim: Alzheimer’s disease (AD) poses a significant health-care challenge, often linked to cognitive decline caused by oxidative stress. This study investigated the potential neuroprotective effects of the Paederia foetida leaf extract (PFE) in rats that exhibited scopolamine-induced dementia mimicking AD.

Materials and Methods: Forty-two male rats were treated with either donepezil (0.5 mg/kg) or PFE at doses of 250, 500, and 1000 mg/kg for 14 days before and 14 days after the beginning of Alzheimer’s-like symptoms after 14 consecutive days of scopolamine administration. Behavioral tests, including the open-field test for locomotor activity and the Morris water maze task for learning and memory assessment, were conducted. Neuronal cell counts and biochemical assays were performed to further analyze outcomes.

Results: All groups exhibited normal locomotor activity. The scopolamine group displayed longer escape latency times, reduced time in the target quadrant, decreased number of surviving neurons, and increased malondialdehyde and decreased glutathione levels compared with the control group. However, pre-treatment with 1000 mg/kg PFE notably mitigated the neurotoxic effects of scopolamine.

Conclusion: The neuroprotective properties of PFE are highlighted, suggesting its potential as a promising treatment strategy for AD.

Keywords: Alzheimer’s disease, neuroprotection, oxidative stress, Paederia foetida, scopolamine.

How to cite this article: Pakaprot N, Khamphaya T, Kwankaew P, Ninsuwan S, Laisunthad S, Thonoi K, and Kuraeiad S (2024) Neuroprotective effects of Paederia foetida Linn. on scopolamine-induced cognitive impairment in rats, Veterinary World, 17(9): 1972-1982.

Received: 2024-05-01 Accepted: 2024-07-29 Published online: 2024-09-01

Corresponding author: Saruda Kuraeiad E-mail: saruda.ku@wu.ac.th

DOI: 10.14202/vetworld.2024.1972-1982

Copyright: Pakaprot, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.