Abstract

Background and Aim: The overuse of antimicrobials in food-producing animals, particularly poultry, has led to growing concerns about multidrug microbial resistance, posing significant risks to both animal and human health. Subtherapeutic doses of antibiotics have traditionally been used to enhance growth and improve economic efficiency in poultry farming. However, these practices have facilitated the emergence of resistant microbial strains, threatening global health security and prompting a search for sustainable alternatives. This review highlights the significance of phytogenic as feed additives (PFAs) as promising substitutes for antibiotic as feed additives (AFAs) in poultry production. PFAs, derived from plant-based compounds, exhibit multiple beneficial properties, including antimicrobial, antioxidative, anti-inflammatory, and immune-modulatory effects. Moreover, they offer the potential to produce high-quality organic poultry products while reducing the likelihood of microbial resistance. Despite these advantages, inconsistent results among studies underscore the importance of standardized approaches to maximize their efficacy. This review aims to evaluate the current status of antibiotic use in poultry farming globally, explore the properties and mechanisms of PFAs, and assess their potential as viable alternatives to antibiotics. By consolidating available knowledge, this review provides insights into the benefits and challenges associated with PFAs, offering guidance for future research and practical applications in sustainable poultry production.

Keywords: alternatives, antibiotics, phytogenic, poultry production.