Cannabidiol reverses depression-like behaviors by enhancing hippocampal synaptic plasticity in rats with chronic restraint stress

Veterinary World Volume 18, Issue 9

Sep 2025

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ARTICLE

Cannabidiol reverses depression-like behaviors by enhancing hippocampal synaptic plasticity in rats with chronic restraint stress

Jutamas Ruanpang , Namphung Thongta , Anchalee Vattarakorn , Sukonthar Ngampramuan , Pornjira Pariwatcharakul , Sompol Tapechum , Chit Care , Narawut Pakaprot
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¹ Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

² Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

³ Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

⁴ Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.

⁵ Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

⁶ Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

⁷ Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

⁸ Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.

Corresponding Author: Narawut Pakaprot (narawut.pak@mahidol.ac.th)

Ruanpang et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License.

https://doi.org/10.14202/vetworld.2025.2823-2838

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Veterinary World

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Cannabidiol reverses depression-like behaviors by enhancing hippocampal synaptic plasticity in rats with chronic restraint stress

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