Comparison of the first Iranian native Ornithobacterium rhinotracheale vaccine with conventional vaccine: A challenge study

Vet World Vol.13 April-2020 Article-7

Research Article

Veterinary World, 13(4): 655-660

https://doi.org/10.14202/vetworld.2020.655-660

N. Ghasemipour¹, H. Goudarzi², M. Banani², and K. Asasi¹

1. Department of Clinical Sciences, Poultry Diseases Research Center, Veterinary School of Shiraz University, Shiraz, Iran.
2. Department of Avian Diseases Research and Diagnosis, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization, Karaj, Iran.

Background and Aim: The best strategy to prevent or control an Ornithobacterium rhinotracheale (ORT) infection is vaccination. The present study aimed to compare the efficacy of the first Iranian inactivated ORT vaccine (Razi, Iran), which had been prepared from a native strain, with the Nobilis ORT Inac (Intervet, The Netherlands) through a challenge trial.

Materials and Methods: Seventy-two 1-day-old specific pathogen-free White Leghorn chickens were used in this study. The birds were divided randomly into four groups. Following the vaccination and challenge of the birds, the efficacy of the Razi and the Intervet ORT vaccines was evaluated by serological, bacteriological, and molecular methods.

Results: The antibody titer in vaccinated groups was determined to be significantly higher than unvaccinated birds. In addition, the difference in postmortem lesion scores between the vaccinated and unvaccinated birds was significant. The differences in the means of the antibody titers and postmortem lesion scores in birds that were vaccinated by the Razi and Intervet ORT vaccines were not significant.

Conclusion: Considering the results of this study, it can be concluded that the Iranian native ORT vaccine was comparable to the Intervet vaccine. The Razi ORT vaccine has effectively decreased the duration of the ORT infection and can effectively protect the chickens against an ORT infection. Keywords: challenge, chickens, efficacy, Ornithobacterium rhinotracheale, polymerase chain reaction, vaccine.

Keywords: challenge, chickens, efficacy, Ornithobacterium rhinotracheale, polymerase chain reaction, vaccine.

How to cite this article: Ghasemipour N, Goudarzi H, Banani M, Asasi K (2020) Comparison of the first Iranian native Ornithobacterium rhinotracheale vaccine with conventional vaccine: A challenge study, Veterinary World, 13(4): 655-660.

Received: 10-11-2019 Accepted: 10-02-2020 Published online: 12-04-2020

Corresponding author: K. Asasi E-mail: asasi@Shirazu.ac.ir

DOI: 10.14202/vetworld.2020.655-660

Copyright: Ghasemipour, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.