Review (Published online: 14-06-2023)
23. Virulence factors and quorum sensing as targets of new therapeutic options by plant-derived compounds against bacterial infections caused by human and animal pathogens
Warangkana Kitpipit, C. Norman Scholfield, Suthinee Sangkanu, Veeranoot Nissapatorn, Maria de Lourdes Pereira, Alok K. Paul, and Watcharapong Mitsuwan
Veterinary World, 16(6): 1346-1355
Warangkana Kitpipit: Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand; One Health Research Center, Walailak University, Nakhon Si Thammarat, 80160, Thailand; Food Technology and Innovation Center of Excellence, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
C. Norman Scholfield: Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand; One Health Research Center, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Suthinee Sangkanu: School of Allied Health Sciences, Southeast Asia Water Team, World Union for Herbal Drug Discovery, and Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Veeranoot Nissapatorn: School of Allied Health Sciences, Southeast Asia Water Team, World Union for Herbal Drug Discovery, and Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Maria de Lourdes Pereira: Department of Medical Sciences, CICECO-Aveiro Institute of Materials, University of Aveiro, Aveiro, Portugal.
Alok K. Paul: School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia.
Watcharapong Mitsuwan: Akkhraratchakumari Veterinary College, Walailak University, Nakhon Si Thammarat, 80160, Thailand; One Health Research Center, Walailak University, Nakhon Si Thammarat, 80160, Thailand; Center of Excellence in Innovation of Essential Oil and Bioactive Compounds, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
doi: 10.14202/vetworld.2023.1346-1355
Article history: Received: 17-03-2023, Accepted: 25-05-2023, Published online: 14-06-2023
Corresponding author: Watcharapong Mitsuwan
E-mail: watcharapong.mi@wu.ac.th
Citation: Kitpipit W, Scholfield CN, Sangkanu S, Nissapatorn V, Pereira MDL, Paul AK, and Mitsuwan W (2023) Virulence factors and quorum sensing as targets of new therapeutic options by plant-derived compounds against bacterial infections caused by human and animal pathogens, Veterinary World, 16(6): 1346-1355.
The emergence of antibiotic-resistant bacteria and hospital-acquired bacterial infection has become rampant due to antibiotic overuse. Virulence factors are secondary to bacterial growth and are important in their pathogenesis, and therefore, new antimicrobial therapies to inhibit bacterial virulence factors are becoming important strategies against antibiotic resistance. Here, we focus on anti-virulence factors that act through anti-quorum sensing and the subsequent clearance of bacteria by antimicrobial compounds, especially active herbal extracts. These quorum sensing systems are based on toxins, biofilms, and efflux pumps, and bioactive compounds isolated from medicinal plants can treat bacterial virulence pathologies. Ideally, bacterial virulence factors are secondary growth factors of bacteria. Hence, inhibition of bacterial virulence factors could reduce bacterial pathogenesis. Furthermore, anti-virulence factors from herbal compounds can be developed as novel treatments for bacterial infection. Therefore, this narrative review aims to discuss bacterial virulence factors acting through quorum sensing systems that are preserved as targets for treating bacterial infection by plant-derived compounds.
