Vet World Vol.17 December-2024 Article - 20
Research Article
Veterinary World, 17(12): 2909-2917
https://doi.org/10.14202/vetworld.2024.2909-2917
Protective effects of Delonix regia and gum Arabic against aluminum chloride-induced toxicity in male Albino Rats
2. Department of Biology, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.
3. Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
4. Department of Animal Productions, Faculty of Agriculture, Al-Azhar University, 71524, Assiut, Egypt.
Background and Aim: Aluminum (AL) is commonly found in food, drinking, air, and soil and it can be a serious contaminant in varying amounts. Therefore, this study investigated the biochemical and histological hazardous reactions to aluminum chloride (AlCl3) and the efficiency of the methanol extract of Delonix regia aerial parts with gum Arabic (GA) as anti-toxic therapies to return to a natural state after AlCl3 exposure.
Materials and Methods: A total of 20 male Wistar rats were randomly divided into four equal groups. (i) CG: Served as a control group. (ii) AlCl3: Rats were exposed to 80 mg/kg/body weight (BW) AlCl3. (iii) AlCl3 + D. regia/GA: rats were administered AlCl3 + 100 mg/kg B.W. with 15% BW of D. regia and GA, respectively. (iv) D. regia/GA: Rats were administered 100 mg/kg B.W. with 15% BW D. regia and GA, respectively. The experimental treatment was administered for 30 days. On the 30th day, blood biochemical parameters were assessed, and specimens from the liver and kidney were collected and stored in a neutral buffer with 10% formalin until immediate histopathological examination after euthanasia.
Results: This study revealed a significant increase in white blood cells and platelets after AlCl3 exposure compared with CG, while there was a decrease in red blood cells, hemoglobin, hematocrit, and mean corpuscular volume. Treatment with D. regia/GA improved lymphocytes, monocytes, eosinophils, and basophils. Furthermore, the animals exposed to AlCl3 showed a significant increase in aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase compared with CG, whereas AlCl3 + D. regia/GA treatment improved these activities. In addition, the rats exposed to AlCl3 had significantly increased glucose, lipase, amylase, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein levels, and D. regia/GA treatment significantly improved these levels compared with AlCl3. This study reported no significant differences in Ca and Na concentrations among groups, but rats exposed to AlCl3 had elevated K, Cl, and Mg levels, whereas D. regia/GA treatment improved these levels.
Conclusion: The co-administration of the methanolic extract of D. regia with GA can protect against AlCl3 toxicity.
Keywords: aluminum, Delonix regia, gum Arabic, toxicity, Wistar Rats.
How to cite this article: Al-Doaiss AA, Alshehri MA, Shati AA, Almaawari AM, Al-Shahrani HS, Saeed AM, Al-Ghamdi AM, Al-Shahrani AS, Almansour MH, El-Mansi AA, Al‑Zharani M, Mubarak M, and Ali ME (2024) Protective effects of Delonix regia and gum Arabic against aluminum chloride-induced toxicity in male Albino Rats, Veterinary World, 17(12): 2909-2917.
Received: 2024-10-03 Accepted: 2024-11-27 Published online: 2024-12-19
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.2909-2917
Copyright: Al-Doaiss, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
