Vet World Vol.17 March Article - 22
Research Article
Veterinary World, 17(3): 700-704
https://doi.org/10.14202/vetworld.2024.700-704
Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats
1 Departamento de Farmacologia, Facultad de Farmacia y Bioquimica, Universidad Nacional de Trujillo, Peru.
2 Departamento de Estadistica, Facultad de Ciencias Fisicas y Matematicas, Universidad Nacional de Trujillo, Peru.
3 Departamento de Matematicas, Facultad de Ciencias Fisicas y Matematicas, Universidad Nacional de Trujillo, Peru.
Background and Aim: Ambrosia arborescens Mill. (A. arborescens) is an aromatic plant used in traditional medicine as an anti-inflammatory, anti-tussive, anti-rheumatic, and anti-diarrheal agent. This study aimed to evaluate the effect of A. arborescens Mill. on a Rattus norvegicus var. albinus-induced breast cancer model.
Materials and Methods: We collected A. arborescens from the province of Julcan, La Libertad Region, Per, and prepared an ethanolic extract using pulverized leaves macerated in 96° ethanol for 72 h with magnetic stirring. In the evaluation of anticancer activity, four experimental groups with 10 female rats each were formed: Group I (Control-7,12-dimethylbenz[a] anthracene [DMBA]), which received DMBA (single dose) and physiological saline solution for 4 months, and Groups II, III, and IV, which received DMBA (single dose) and 200, 400, and 600 mg/kg/day of the ethanolic extract of A. arborescens, respectively, for 4 months.
Results: The DMBA control group presented histological characteristics of ductal carcinoma in situ with necrotic and inflammatory areas, whereas the A. arborescens extract group showed a decrease in tumor volume and recovery of the ductal duct.
Conclusion: Ethanol extract of A. arborescens leaves decreases tumor development in rats with induced breast cancer, and this effect is dose-dependent.
Keywords: 7,12-dimethylbenz[a]anthracene, Ambrosia arborescens, breast carcinoma in situ, cancer, rat.
How to cite this article: Silva-Correa CR, Villarreal-La Torre VE, Lozano-Ciudad GE, Gomez-Arce RM, Castaneda-Carranza JA, Dionicio-Rosado DY, Cotrina-Leon ME, Sagastegui-Guarniz WA, Gamarra-Sanchez CD, and Cruzado-Razco JL (2024) Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats, Veterinary World, 17(3): 700-704.
Received: 11-12-2023 Accepted: 04-03-2024 Published online: 25-03-2024
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.700-704
Copyright: Silva-Correa, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
