Vet World Vol.17 November-2024 Article - 13
Research Article
Veterinary World, 17(11): 2537-2543
https://doi.org/10.14202/vetworld.2024.2537-2543
Genome-wide association study of genetic markers of coat color patterns in Sumatran native cattle
2. Research Center for Applied Zoology, National Research and Innovation Agency (BRIN), Bogor 16911, Indonesia.
3. Research Center for Sustainable Production System and Life Cycle Assessment, National Research and Innovation Agency (BRIN), Banten, Indonesia.
4. Directorate of Laboratory Management, Research Facilities, and Science and Technology Areas, Deputy for Research and Innovation Infrastructure, National Research and Innovation Agency (BRIN), Indonesia.
5. Department of Animal Science, Faculty of Agriculture , Islamic University of Kuantan Singingi, Teluk Kuantan Riau, Indonesia.
6. Department of Animal Husbandry and Veterinary Science, West Sumatra Provincial Government, Rasuna Said Street No. 68 Padang, Indonesia.
7. Department of Animal Science, Faculty of Agriculture, University of Lampung 35145, Indonesia.
Background and Aim: Coat color is a phenotypic trait that is affected by many functional genes. In addition, coat color is an important characteristic of breeds in livestock. This study aimed to determine functional genes for coat color patterns in Sumatran native cattle in Indonesia using a genome-wide association study method.
Materials and Methods: A bovine single nucleotide polymorphism (SNP) 50K BeadChip was used for the investigation. A total of 46 Sumatran native cattle of three colors as follows: Brown (36 animals), white (9 animals), and black (1 animal), were used as experimental animals.
Results: Results showed that the SNP markers ARS-BFGL-NGS-75486 (p = 2.46 × 10-7) and BTB-01992588 (p = 1.06 × 10-5) were selected as two genetic markers for coat color variation in animals under study, which were located at the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene at BTA7 and small G protein signaling modulator 1(SGSM1) genes at BTA17, respectively. The polymorphic informative content values of both SNP markers were 0.33 (ARS-BFGL-NGS-75486) and 0.13 (BTB-01992588). In this study, a genetic marker for coat color patterns in Sumatran native cattle was obtained based on the haplotypes of both SNP markers.
Conclusion: It can be concluded that CYFIP2 and SGSM1 are two coloration genes that affect the phenotype characteristics of Sumatran native cattle.
Keywords: cattle, coat color, functional gene, genome-wide association study, Sumatra.
How to cite this article: Hartati H, Putra WPB, Handiwirawan E, Ramon E, Firison J, Zubir Z, Suretno ND, Mariyono M, Yusriani Y, Robba DK, Destomo A, Anggraeni T, Anwar P, Irmawanti S, Aprisal A, Elieser S, and Kurniawati D (2024) Genome-wide association study of genetic markers of coat color patterns in Sumatran native cattle, Veterinary World, 17(11): 2537-2543.
Received: 2024-08-04 Accepted: 2024-10-09 Published online: 2024-11-13
Corresponding author: E-mail:
DOI: 10.14202/vetworld.2024.2537-2543
Copyright: Hartati, et al. This article is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
